Wykład zatytułowany Cartilage regeneration: the challenges of regenerating a "simple" tissue and the use of biomaterials wygłosi prof. Gerjo J.V.M. van Osch (Erasmus MC, University Medical Center Rotterdam and University of Technology Delft, Holandia).
Since the inception of Tissue Engineering and Regenerative Medicine, cartilage has been a target tissue. It was thought this would be a relatively simple tissue to engineer, consisting of one cell type and no blood vessels or nerves. Moreover, there was and remains an unmet clinical need for functional repair of cartilage defects. This led to the development of one of the first cell therapies in clinical application (i.e. Autologous Chondrocyte Implantation) and efforts are ongoing to develop new and improved cartilage repair therapies. However, despite the fast inclusion and utilisation of new technologies from other areas - such as stem cell biology, immunology, molecular imaging, biomaterials and additive manufacturing/3D-printing that opened up possibilities for large steps forward in the improvement of cartilage repair- it remains still challenging to regenerate functional articular cartilage. Research in the past years have taught us much about the capacity of different types of chondrocytes as well as bone marrow derived mesenchymal stromal cells to generate cartilage. Knowledge from developmental and cell biology, immunology, matrix biology and material sciences has helped to deepen our understanding of cartilage and to improve methods to generate stable and functional cartilage. Driven by the still unmet clinical need to repair damaged cartilage in patients, with support of innovative technologies and from a deeper understanding of basic biological processes, we are getting closer to the enginering of functional cartilage.